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Thesis renewed

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Role of platelets and leukocytes in
hypercoagulable state seen in Cov-19 patients
MD Thesis
by
Lina Hatangimana
Supervisor
Dr. Tihamér Molnár
Associate Professor
Department of Anesthesiology and Intensive Therapy
Medical School
University of Pécs
Hungary
2021
Contents
1. Introduction
1. SARS-Cov2 infection
2. Hypercoagulable state
3. Role of platelets in coagulopathies
4. Leukocyte antisedimentation rate (LAR)
5. Aims and outcome measures
2. Materials and methods
1. Materials
2. Methods
3. Statistical analysis
4. Ethics
3. Results
4. Discussion
5. Conclusion
1. Introduction
1.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONA VIRUS 2
Covid 19 disease is still a global threat to health as confirmed cases of infection with the
severe acute respiratory syndrome corona virus 2 (SARS-CoV2) continuesly increase.
Coronaviruses are a family of enveloped RNA viruses causing acute and chronic diseases.
Unlike other coronavirus types, transmission before symptom onset is seen more readily in
infection with SARS-CoV2, which explains its fast spread seen globally. It’s ability to infect
the upper resporatory tract especially r
Effectively transmitted through aerosol or fomites, SARS-CoV2 infects cells of the
respiratory system causing excessive inflamation and cell death. Angiotensin converting
enzyme 2 (ACE2) acts as the receptor for SARS-CoV2 entering the cells (Harrison et al.,
2020). Consequently, the virus spreads out and damages other vital organs and tissue,
triggering a complicated spectrum of pathophysiological changes and symptoms.
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