Role of platelets and leukocytes in hypercoagulable state seen in Cov-19 patients MD Thesis by Lina Hatangimana Supervisor Dr. Tihamér Molnár Associate Professor Department of Anesthesiology and Intensive Therapy Medical School University of Pécs Hungary 2021 Contents 1. Introduction 1. SARS-Cov2 infection 2. Hypercoagulable state 3. Role of platelets in coagulopathies 4. Leukocyte antisedimentation rate (LAR) 5. Aims and outcome measures 2. Materials and methods 1. Materials 2. Methods 3. Statistical analysis 4. Ethics 3. Results 4. Discussion 5. Conclusion 1. Introduction 1.1 SEVERE ACUTE RESPIRATORY SYNDROME CORONA VIRUS 2 Covid 19 disease is still a global threat to health as confirmed cases of infection with the severe acute respiratory syndrome corona virus 2 (SARS-CoV2) continuesly increase. Coronaviruses are a family of enveloped RNA viruses causing acute and chronic diseases. Unlike other coronavirus types, transmission before symptom onset is seen more readily in infection with SARS-CoV2, which explains its fast spread seen globally. It’s ability to infect the upper resporatory tract especially r Effectively transmitted through aerosol or fomites, SARS-CoV2 infects cells of the respiratory system causing excessive inflamation and cell death. Angiotensin converting enzyme 2 (ACE2) acts as the receptor for SARS-CoV2 entering the cells (Harrison et al., 2020). Consequently, the virus spreads out and damages other vital organs and tissue, triggering a complicated spectrum of pathophysiological changes and symptoms.