930 Abstract citation ID: igad104.2987 Abstract citation ID: igad104.2988 PARO ROBOT INTERACTION DECREASES PAIN AND AGITATION SCORES IN HOSPITALIZED OLDER ADULTS WITH ADRD AND/OR DELIRIUM Pamela Cacchione1, Ellen Munsterman2, Lisa Walke2, Lisa Triantos3, Michelle Johnson2, and Jodi Cheeks3, 1. University of Pennsylvania School of Nursing; Penn Presbyterian Medical Center, Philadelphia, Pennsylvania, United States, 2. University of Pennsylvania, Philadelphia, Pennsylvania, United States, 3. Penn Presbyterian Medical Center, Philadelphia, Pennsylvania, United States Hospitals are stressful for persons with Alzheimer’s Disease and Related Disorders (ADRD) and/or delirium. Therapeutic robotic animals, used in long-term care, are gaining traction in hospitals to decrease agitation. The purpose of this RCT was to 1) test the effectiveness of the PARO Robot in decreasing agitation (CMAI-OT) and pain, (PAINAD); 2) quantify the interactions (SIT) with PARO over 2 visits in persons with ADRD and/or delirium. We enrolled 45 intervention and 42 attention control (2 one-hour PARO interactions vs. research assistant interactions) participants. The CMAI-OT and PAINAD were completed at baseline and every 20 minutes X 3 in both groups. No differences between groups on age (M=83.7), gender (63% female), race (77 % Black) number of antipsychotics prescribed [M=1.2 vs M1.5, p=0.14], or baseline CMAI-OT scores PARO vs control [M=9.3 vs M=9.4, p=0.94]. CMAI-OT decreased at 20 minutes in the PARO group [M=3.9 vs. M=7.0, p= .004] and remained lower for the hour but not significantly. PAINAD scores were similar at baseline [M=2.0 vs M=2.2, p=0.65]. PAINAD scores decreased for PARO vs. control [M= 1.64 vs. M= 2.28, p=0.02; M=0.9 vs. M= 1.8, p=0.03] at 20 & 60 minutes day one without differences day two. Participants held PARO; engaged physically; talked to; smiled; and agreed to have PARO return. We demonstrated improved agitation for first 20 minutes of PARO interaction as well as lower pain over the first 60 minutes day one. Findings did not persist through day two. Next steps are to measure emotional responses to PARO. SESSION 7870 (POSTER) MICROBIOME AND AGING Abstract citation ID: igad104.2989 A NEW ROLE FOR KYNURENINE METABOLISM IN THE AGE-ASSOCIATED DECLINE OF THE BACTERIAL IMMUNE RESPONSE George Sutphin, and Luis Espejo, University of Arizona, Tucson, Arizona, United States Tryptophan metabolism through the kynurenine pathway becomes dysregulated during normal aging and is implicated in age-associate disease, including chronic inflammation, atherosclerosis, neurodegeneration, and cancer. Kynurenine pathway enzymes and metabolites influence a range of molecular processes critical to healthy aging, including regulation of inflammatory and immune responses. Kynurenine metabolism is active in immune cells and activated in response to proinflammatory cytokine signaling. We previously determined that elevating physiological levels of the kynurenine pathway metabolite 3-hydroxyanthranilic acid (3HAA) via either direct supplementation or inhibition of the enzyme that degrades 3HAA, 3HAA dioxygenase (HAAO), extends lifespan and delays age-associated health decline in Caenorhabditis elegans. Published work suggests that 3HAA is anti-inflammatory in mammals, for example by reducing the ratio of activated to regulatory T cells and inhibiting pathological activation of macrophages. In recent work, we find that elevating physiological 3HAA can beneficially enhance the immune response of C. elegans to bacterial pathogens during aging. 3HAA is sufficient to kill bacterial and inhibit bacterial growth in culture. When HAAO is inhibited in C. elegans, 3HAA accumulates in lysosome related organelles (LROs) in the intestinal cells, the same subcellular compartment that contains engulfed bacteria. LROs are a cellular repository for both iron and zinc, and we further find that iron chelation or zinc supplementation dramatically enhances the bactericidal properties of 3HAA. Here we present a mechanistic model in which age-dependent accumulation of 3HAA in intestinal LROs combines with zinc to enhance bacterial resistance with age in C. elegans. Downloaded from https://academic.oup.com/innovateage/article/7/Supplement_1/930/7490736 by Biotech Info Service, CTT, EMA user on 22 December 2023 LEVERAGING NURSING ASSESSMENT DATA TO IDENTIFY FRAILTY INDICATORS OF HOSPITAL DISCHARGE DISPOSITION Sarah Ser1, Laurence Solberg2, Ragnhildur Bjarnadottir1, Robert Lucero3, Mattia Prosperi1, Urszula Snigurska4, and Brian Celso5, 1. University of Florida, Gainesville, Florida, United States, 2. NF/SG VHS, Newberry, Florida, United States, 3. University of California, Los Angeles, Los Angeles, California, United States, 4. University of Florida College of Nursing, Gainesville, Florida, United States, 5. University of Florida Jacksonville, Jacksonville, Florida, United States Frailty among older adults is associated with higher morbidity and mortality rates and poorer hospital outcomes. Although frailty is not routinely assessed in the hospital setting, elements of frailty are captured in nursing assessments. The purpose of this study was to examine components of the Risk Analysis Index (RAI) captured in electronic health record (EHR) assessment data and their associations with discharge disposition. This was a retrospective observational study of EHR assessment data which included encounters of older adult patients (≥ 65 years) who were admitted from home to a medical/surgical unit of an academic hospital in North Central Florida between January 2012 and May 2021. The components of the RAI included in the study were sex, age, cancer, renal failure, heart failure, cognitive decline, unintentional weight loss, poor appetite, and shortness of breath at rest. Descriptive statistics were generated and compared between patients discharged to home versus those who were discharged to Post-Acute Care (PAC) facilities. Unadjusted associations were assessed using univariate logistic regression. Consistent with existing literature on frailty, all but one of the included RAI components (i.e., male sex) exhibited higher odds of discharge to a PAC facility with strong statistical support. Recognizing functional decline due to frailty is integral to the mission of improving patient safety. This study provides a preliminary proof of concept for leveraging existing assessment data in the EHR to capture frailty in older adults. Future studies of the overall predictive value of RAI with disposition are warranted. Innovation in Aging, 2023, Vol. 7, No. S1