A
1.2
Driver genes
Essential genes
All genes
Av erage gravitation
COAD
0.9
0.6
0.3
0
B
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X
Ch romosome
Driver genes
Essential genes
All genes
0.9
Av erage gravitation
HNSC
0.6
0.3
0
C
Av erage gravitation
2.5
2
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X
Ch romosome
Driver genes
Essential genes
All genes
KIRC
1.5
1
0.5
0
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X
Ch romosome
Fig. S17. The average gravitation score distribution of cancer driver genes, essential genes, and all genes
across chromosomes for 6 cancer types: (A) COAD: colon adenocarcinoma, (B) HNSC: head and neck
squamous cell carcinoma, (C) KIRC: kidney renal clear cell carcinoma, (D) LUAD: lung adenocarcinoma,
(E) LUSC: lung squamous cell carcinoma, and (F) OV: ovarian serous cystadenocarcinoma. Left box plot
shows the cancer driver gene average gravitation between X chromosome and the entire 22 autosomes.
The p-values are calculated by the Wilcoxon sum-rank test and corrected by R package multiple test.
Fig. S17. continue...
D 0.9
Driver genes
Essential genes
All genes
Av erage gravitation
LUAD
0.6
0.3
0
E 0.9
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X
Ch romosome
Driver genes
Essential genes
All genes
Av erage gravitation
LUSC
0.6
0.3
0
Av erage gravitation
F 0.9
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X
Ch romosome
Driver genes
Essential genes
All genes
OV
0.6
0.3
0
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X
Ch romosome
