BBMRI.se
Prof. Jan-Eric Litton
[email protected]
Budget
Swedish Research Council 2009
Karolinska Institutet
2010
140 MSEK
30 MSEK
Budget
Swedish Research Council 2009
Karolinska Institutet
2010
All other Medical faculties 2012
140 MSEK
30 MSEK
12,5 MSEK
Budget
Swedish Research Council 2009
Karolinska Institutet
2010
All other Medical faculties 2012
140 MSEK
30 MSEK
12,5 MSEK
21,2 M€
Budget
Swedish Research Council 2009
Karolinska Institutet
2010
All other Medical faculties 2012
140 MSEK
30 MSEK
12,5 MSEK
21,2 M€
Executive Director to 1/1 2015 Prof. Jan-Eric Litton
New application 2014.
BBMRI.se – a unified Swedish
infrastructure for biobanking
WP1 – Project management
WP2 & WP3
WP4
WP5
WP6
WP7
WP8
Collection:
Input
Analysis:
Output
IT
Physical
Facility
Ethics
Financing
Coordinate &
harmonize
sample / data
collection from
populations &
hospitals
Optimize
interface to
analysis
resources
Distributed sample
handling at local
biobanks and hospitals
Enforce a
unifying
national IT
platform
Create an
efficient
national, large
scale sample
handling
platform
Central storage
and withdrawal
Provide
Ensure longnational
term financing
expertise and
forum to
address
ethical issues
Static freezers store ~100
million tubes = “hard drive”
Automatic re-picking unit for
fast retrieval = “processor &
RAM memory”
Large-Scale Swedish Biobank (SSB); a
service facility for big national studies
Assembled a national biobank of > 3 million samples
SSB has transformed sample
handling
• Modern sample format
• Highly automated
•
Fast in – Fast out
• Highly traceable, secures integrity
•
For donor, sample, data
• Higher quality
• Lower cost
• Continuous improvement
•
Plenty of improvements to come!
BMMRI.se is distributed in a hub- and
spoke structure
BBMRI.se organisation
NUMBER OF
EMPLOYEES
WP
WP1
WP2
WP3
WP4
WP5
WP6
WP7
WP8
Total
3
10
1
4
3
15
6
1
43
persons
persons
person
persons
persons
persons
persons
persons
persons
NUMBER OF
EMPLOYEES
AREA
FTE
1
6
1
2
3
10
3
1
26
FTE
Uppsala
Umeå
Göteborg
Linköping
Lund
Stockholm
11
4
1
1
2
24
persons
persons
person
person
persons
persons
5
3
0
1
1
17
Total
43 persons
26
Members in the workgroups
National university assembly:
Mats Karlsson (Örebro), Lars Lind (Uppsala), Lauren Lissner (Göteborg), Lennart Eriksson
(Stockholm), Maria Fällman (Umeå), Peter Nilsson (Lund/Malmö), Peter Söderkvist
(Linköping), Sonja Eaker Fält (NBR)
SAB:
Kristian Hveem (Professor, HUNT research center, DMF, BBMRI.no, Norway)
Gert-Jan B. van Ommen (Professor, Leiden University Medical Center, BBMRI.nl, The
Netherlands)
Fay Betsou (Chief Biospecimen Science, Integrated Biobank of Luxembourg, Luxembourg)
Alison Spaull (Canadian Partnership for tomorrow Project, Canada/Scotland)
Marianne K. Henderson (President ISBER, USA/National cancer institute, USA)
Executive board: Håkan Billig (Gothenburg University), Anu Jalanko (The National Institute for
Health and Welfare, Finland), Maria Anvret (Sahlgrenska akademin, Gothenburg), Maria
Fällman (Umeå University), Mathias Uhlén (Science For Life Laboratory, Stockholm), Tobias
Nilsson (Stockholm County Council, SL
Executive Director:
Jan-Eric Litton (Professor) and Joakim Dillner (Professor) as deputy director.
GSB:
Jan-Eric Litton (BBMRI.se) and Göra Elinder (NBR)
Biobank landscape of Sweden
• 579 Biobanks
Biobank landscape of Sweden
GSB
Mission from The
Swedish research
council (VR) and
Swedish
Association of
Local Authorities
and Regions
(SKL)
Biobank landscape of Sweden
GSB
Mission from The
Swedish research
council (VR) and
Swedish
Association of
Local Authorities
and Regions
(SKL)
Biobank landscape of Sweden
– for healthcare
Tissue 114 M sampels
Cells 28, 7 M
Blood/plasma 4530000
Serum 2200000
DNA/RNA 69000
Bone 110000
Others 106000
Pilot large-scale, national biobanking
solution in Health Care:
Liquid Based Cytology700 000 women sampled/year
• Cervical cell samples collected in National Cervical Screening program
• Targets all women in Sweden between 23-60 years old.
• Liquid to preserve cells, DNA, RNA & protein for future research.
• BBMRI.se offers highly effective biobanking solution to major cytology laboratories
• eg: Stockholm county: > 68 000 cell samples stored so far
Pilot large-scale, national biobanking
solution in Health Care:
Liquid Based Cytology700 000 women sampled/year
Biobank landscape of Sweden
– for research
Blood/Plasma 4,2 M
Serum 2,3 M
DNA/RNA 572000
Tissue 51000
Urin 230000
Salivia 112000
Other 47000
The Swedish Biobank Registry
Tissue 114 M
sampels
Cells 28, 7 M
Blood/plasm
a 4530000
Serum
2200000
Blood/Plasma
4,2 M
Serum 2,3 M
DNA/RNA
572000
Tissue 51000
Urin 230000
The Swedish Biobank Registry
Health care
e-biobank
2012-01-18
Report engine
to the National
Board of
Health and
Welfare
Common
attribute
Healtcare
BBMRI.se
Research
BBMRI.se
Minimum Information About
Biobank data Sharing – MIABIS 2.0
Number of Sample Collections registered in
BBMRI.se – October 2012 release
Legal entity
Number
Göteborg Universitet
Hälsohögskolan i Jönköping & KI
Hälsouniversitetet Linköping
Karolinska Institutet
Landstinget i Värmland
Landstinget i Östergötland
Lunds Universitet
Norrbottens Läns Landsting
1
1
10
29
1
1
11
1
Skånes Universitetssjukhus
Stockholms Läns Landsting
Umeå universitet
Uppsala universitet
6
12
5
1
Total
79
biobankCloud – EU FP7 infrastructure for
sensitive Big Data
BBMRI.se collaboration with:
• Royal Institute of Technology, Sweden
• Humbolt University, Berlin
• Charité Universitätsmedizin, Berlin
• Fundação Faculdade de Ciências da
Universidade de Lisbon
Start November 1st.
BBMRI.se is exceptionally well connected internationally
Collaboration
Nature
Program
BioSHaRE
International sharing of tools and biobank sample
EU FP7
HEALTH 2010-1.1-1
BioMedBridge
Infrastructure for medicine in EU- standards
EU FP7, INFRA- 2011-2.3.2
Gen2Phen
Unifying genetic variation database
EU FP7, HEALTH2007
EuroCoures
Cancer Register use
EU FP7
ERA-NET-2007
SeRC
Swedish e-science
National
BILS
Bioinforamtics infrastructure - ELEXIR
National
CPAC
Canadian Partnership against cancer
SAB
p-Medicine
Personalised medicine inovation
SAB
Connect RD
Rare diseases
EU FP7. HEALTH 20122.1.1-1
Nordic cancer pilot
Causes and biomarkers
Nordic BBMRI
ISBER
International society for biological and
Enviromental Repositories
International
P3G
PublicPopulation Project in Genomics
International
BBMRI LPC
Large Prospective Cohortstudies
EU FP7, INFRA 2012-1.1.9
Biobank Cloud
Storing BIG data
EU FP7, ICT-2011-8
Nordic BBMRI: Aim
•
Launch large-scale collaborative projects based on
pooling of samples, data and services from the
Nordic national biobank infrastructures.
•
Proof of concept: Colon cancer project
•
Plans for a Nordic catalog !
“BBMRI.Nordic” – facilitating collaboration across
BBMRI.SE
BBMRI.NO
BBMRI.FI
Denmark
BBMRI.”IS”
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WP 2
WP 3
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BBMRI.nordic is supported by NordForsk
Nordic biobank information group
Tartu, August 22, 2012
400 people from 27 countries came !!!
400 people from 27 countries came !!!
Next HandsON: BBMRI.nl 20-22 November 2013
[email protected]
