Presbyacusis – aspekter avseende epidemiologi och kognition Ulf Rosenhall kHz 0.25 0.5 1 0 2 4 8 Hur hör vi i Sverige? 20 30 40 20 Johan sson & Arlinger, 2002 L,R 60 40 2 epidemiologiska us. Kvinnor och män, 20 till 90 år gamla 70 70 60 75 80 80 Jönsson & Rosenhall, 1998a,b, L 85 100 Men, 20 - 90 years 90 kHz 0.25 0.5 1 0 2 4 8 20 30 40 20 50 dB HL dB HL 50 Johan sson & Arlinger, 2002 L,R 60 40 70 70 60 75 80 80 85 100 Women, 20-90 years 90 Jönsson & Rosenhall, 1998a,b, L Åldershörselnedsättning Presbyacusis Age-related hearing loss ARHL el. ARHI Förekomst? Orsaker? Åtgärder? Three Swedish Epidemiological Studies 1)The Gerontological and Geriatric Population Study in Gothenburg: H70 (1971-2005) 2) The Study of Men born in 1913 and 1923 (1973) 3) Health and Psychosocial Work Conditions in Middle Aged Women (2005) kHz kHz 0.25 0.5 1 2 4 0.25 8 4 8 50 40 1 70 20 dB HL dB HL 2 60 3 20 60 100 1 0 0 80 0.5 Women, 51.3 y Women, 70 - 90 y Left ear Jönsson & Rosenhall 1998 Hederstierna et al, 2007 2 40 75 79 81 60 85 80 Men, 50 – 60 y 100 Men, 70 - 90 y Left ear Rudin et al, 1988 Pedersen et al, 1989 1 88 90 Men, L ear, 70-80/75 years Men and women, 70 - 80 y 5 epidemiological studies from Europe and USA Unscreened populations kHz 0.25 0.5 1 2 3 4 6 8 10 20 30 G ates et al. 199 0 Davi s 19 95 50 Jöns son & Ros enhall 199 8 60 Crui cks hanks et al. 19 98 70 Engdahl et al . 2005 80 Women, L ear, 70-80/75 years 90 kHz 0.25 0.5 1 2 3 4 6 8 10 20 Remarkable good agreement between different studies from developed countries 30 G ates et al . 1990 40 dB HL dB HL 40 Davi s 1995 50 Jöns s on & Rosenhal l 1998 60 Crui cks hanks et al . 1998 70 80 90 Engdahl et al. 2005 Men, L/B ear, 80-90/85 years k Hz 0.25 0.5 1 2 3 4 6 8 10 20 G ates et al. 1990 40 Parving et al. 1997 50 Jöns son & Ros enhall 1998 Crui cks hanks et al. 1998 60 Hietanen et al. 2004 70 Engdahl et a. 2005 80 Women, L/B ear, 80-90/85 years 90 k Hz 0.25 0.5 1 2 3 4 6 8 10 The prevalence of child and adult hearing impairment is substantially higher in middle- and low-income countries than in high-income countries, demonstrating the global need for attention to hearing impairment Stevens et al, 2013 dB HL dB HL 30 Men and women, 80 - 90 y 6 epidemiological studies from Europe and USA Unscreened populations 20 30 G ates et al . 1990 40 Parvi ng et al . 1997 50 Jöns son & Ros enhal l 1998 Crui ckshanks et al. 1998 60 70 80 90 Hietanen et al. 2004 Engdahl et al. 2005 Gender differences 70 - 80 y, 80 - 90 y Ge n der Di ffe re n ce , 70-80 years 25 20 G ates et al. 1990 Pears on et al. 1995 10 Davis 1995 5 Jönss on & Ros enhall 1998 Cruickshanks et al. 1998 0 Ge n der Di ffe re n ce, 80-90 ye ars -5 25 -10 0.25 0.5 1 2 3 4 6 8 20 k Hz G ates et al . 199 0 15 Pears on et al . 199 5 10 Parvi ng et al. 199 7 dB dB 15 Jönss on & Ros enhall 199 8 5 Cruickshanks et al . 199 8 0 Hietanen et al. 20 04 -5 -10 0.25 0.5 1 2 k Hz 3 4 6 8 Hörselskadade i Sverige Självskattad hörselnedsättning (HRF/SCB) >1 milj. Beräknat antal med HNS enligt tonaudiometri 20-70 år Svår HNS – dövhet Måttlig HNS (M4: 40-64 dB): Lätt HNS (M4: 20-39 dB): ~130 000 >0,5 milj. ~1,4 milj. Totalt: >2 milj. 70+ 1/3 2/3 2/3 1/3 Beräkning 2014 Antal svenskar med hörselnedsättning (tusental) 0 – 20 år 20 - 50 år 51 – 70 år >70 år Lätt Måttlig – svår M4 20-39 dB M4 ≥40 dB 43t 229t 629t 474t 5t 45t 161t 430t Sveriges befolkning 31/12 2013 Sveriges befolkning 31/12 2013 Sveriges befolkning 31/12 2013 Ålder, år 60 Beräknat behov, Hörselrehab ~ 5% 70 10 – 20% 80 40 – 45% 90 60 – 70% Andel av befolkningen i Sverige 2009 2015 2060 65+ 15% 17% 25% 80+ 4% 9% 65+ 2,7 milj. 2060 Sweden 2006 90y 80y +70 y More women than men have hearing loss PTA +40 dB 70y 60y PTA <20 dB PTA 20-39 dB PTA 20-39 dB PTA <20 dB 50y Men 50+ 1.6 m Women 50+ 1.8 m Vad händer med hörseln på lång sikt? Är hörseln konstant? Försämras hörseln? Förbättras hörseln? Ökar eller minskar incidensen av hörselproblem? Den pessimistiska synen: Hörselproblemen ökar globalt WHO 2002 - 2030 DALYs (Disability-Adjusted Life Years) Adult onset hearing loss: 2002 ranking # 13 globally Year 2030 estimated ranking # 9 (2.5 DALYs) High-income countries # 7 (4,1 DALYs) Middle-income countries # 9 (2,9 DALYs) Low-income countries < #10 Mathers & Loncar, 2006 The pessimistic view In the Alameda County Study prevalence rates of self-reported trouble with hearing nearly doubled from 1965 to 1994 Wallhagen et al, 1997 Increases in prevalence of hearing loss in adolescents from 15% to 19.5% from 1988–1994 to 2005–2006 NHANES Shargorodsky et al, 2010 Self-assessed hearing loss 1984 - 2005 Statistics Sweden, SCB Marke Trak VIII Kochkin, 2005 11.7 16 14 11.3% 10.8% 10 14 % 8 6 4 Men 2 Total 20 05 20 04 -0 3 02 -0 1 00 -9 9 98 -9 7 96 -9 5 94 -9 3 92 -9 1 90 -8 9 88 -8 7 86 -8 5 0 Year 10.2% 9.9% Women 10.5 % 84 Percent 12 The optimistic view Prevention NIHL – prevention Vaccination programmes ARHL – life-style factors ”Americans hear as well or better today compared with 40 years ago” NHANES, NHES Hoffman et al, 2010 Persons from later birth cohorts had lower prevalences of hearing impairment than those from earlier birth cohorts Beaver Dam Study, EHLS Zhan et al, 2010 The optimistic view 75-year olds over three decades: No audiometric changes The Gerontological and Geriatric Population Study in Gothenburg, Sweden Rosenhall et al, 2013 dB HL 0 dB HL 0 Women 75 Right Ear 10 20 20 30 30 40 50 1RE 40 50 2RE 60 70 80 90 0,25 Men 75 Right Ear 10 1RE 2RE 60 4RE 4RE 70 6RE 80 0,5 1 2 4 6 8 kHz 90 0,25 6RE 0,5 1 2 4 6 8 kHz Förändras hörseln från generation till generation? 18-åriga mönstrande svenska män Prevalence any threshold >= 25 dB HL any ear 3,4 or 6 kHz 18 Prevalence, % 16 14 12 10 8 6 4 2 0 1971 1976 1981 1986 1991 1995 2000 2005 Year Både bättre och sämre (men mest bättre) HNS-prevalens 3 - 6 kHz, något öra, 1971 – 2005 Muhr et al, 2016 18-åriga mönstrande svenska män Lätt, måttlig och svår HNS i diskantområdet 1971 – 2004 (-2010), ett eller båda öronen Histopathology of ARHL Cochlear degeneration • • • • • OHC degeneration in basal and apical coil IHC degeneration in basal coil Strial degeneration Alterations and derangement of hair bundles Intracellular inclusions Types of ARHL 1) Sensory 3 2 4 1 2) Neural uncommon, <1% PARAN Gates et al, 2000 3) Strial (metabolic) 4) Cochlear conductive 5) Mixed hypothetical 6) Indeterminate Schuknecht & Gacek, 1993 Woman 75 y Sensory type Schuknecht’s classification Man 74 y Engström et al. 1987 Strial type Schuknecht, 1994 A reduction in the EP is presumed Presbyacusis Woman 83 y Strial (metabolic) type Schuknecht’s classification Presbyacusis Woman 67 y Gates & Mills, 2005 Presbyacusis Man 73 y Mixed: sensory + strial types Engström et al. 1987 Age, Cohort, and Period Effects Causes of ARHL Intrinsic causes – Age, Cohort Effects Biological ageing Biological ageing is probably only a minor contributor to ARHL of ”younger elderly people”, but increases in importance in advanced age, 80+ Telomeres? Genetic factors Important contributors to ARHL Mutation in mtDNA The 4,977-bp deletion Bai et al, 1997; Ueda et al, 1998 Genetic influences of ARHL in man • ARHL has a multifactorial aetiology • Familial aggregations occur for sensory and strial ARHL phenotypes • Heritability: 35-55% (sensory type) • The heritability estimate was greater for the strial than the sensory phenotypes • Women: Genetic effect on ARHL • Men: Mixed, genetically/aquired ARHL Gates et al, 1999 • Candidate genes in man: 10q26, 11q13.5, 11q25 (DFNB20), 11p, 14q, 18q KCNQ4, DFNA18 DeStefano et al, 2003; Fransen et al, 2003; Garringer et al, 2006; van Eyken et al, 2006; a.o. Genetics and ARHL – Twin Studies Audiometric Study of Male Twins Variation in high frequency hearing is related to genetic and extrinsic factor. Heritability: 47%, 64+ years, men The environmental effect becomes more important with age Karlsson et al, 1997 Danish Twin Registry Heritability for self-reported hearing loss 40%, 75+ years Christensen et al, 2001 NAS-NRC Twin Panel Heritability: 60% (self-reported). HI susceptibility locus on chromosome 3, DFNA18 locus Reed et al, 2000; Garringer et al, 2006 Finnish Twin Study on Aging Heritability: >60%, measured hearing, 63-76 years, women Self-reported hearing related to environmental factors Viljanen et al, 2007 Causes of ARHL Environmental, acquired Period Effects Vocational noise exposure Ototoxic drugs Solvents, other chemicals e.g. carbon monoxide Traumatic hearing loss Infections Middle ear disease Heavy metals (Hg) Noise – Unscreened Occupational Noise - No Noise Men, 70 y Men, 75 y (70-80 y) No Noise v s Occupation al No ise kHz 0.25 0.5 1 2 3 4 The Göte borg Gerontol. Study 6 8 0 0 10 20 20 dB HL dB HL 30 40 No Noise 40 Noise +1 5y 50 60 80 Highly scr eened 60 Noise scr eened 70 Unsc ree ned 80 n: 1 37 NN n: 1 00 N+15y 0.25 0.5 1 2 4 8 kHz Compilation of 8 studies Highly screened for otological disease and noise (green) Screened for noise only (blue) Unscreened studies, noise exposed populations (red) No noise (blue) vs occupational noise (red) H70 Interactions between Noise-Induced Hearing Loss and ARHL Additive effect Noi se and Presbyacusi s Gates e t al., 20 00 (adopted by ISO 1999) 1,75 1,5 Less-than-additive effect Annual Decline, dB/y LE 1,25 1 No Noise Mills et al, 1996; 1998 Noise 0,75 More-than-additive effect 0,5 0,25 Miller et al, 1998 0 0.25 0.5 1 2 3 4 6 8 kHz Combined effect Animal research indicates a sensitising effect of noise Kujawa & Liberman, 2006 Less ARHI in NIHL-frequencies (4-6 kHz) Increased ARHI in neighbouring frequencies, - 2 kHz Gates et al., 2000 Annual decline dB/year Three longitudinal studies H70 Noise vs No Noise Hederstierna, Rosenhall, 2015 BLSA Noise vs No Noise Pearson et al, 1995 MUSC No Noise Lee et al, 2005 Causes of ARHL Environmental, extrinsic Life style factors Every day noise exposure Leisure time noise exposure, e.g. music, shooting Smoking Alcohol (severe abuse) Diet Physical fitness Interfererande sjukdomar Kognitiva störningar – Demens Metabolt syndrom – DM2 AD: 3 – 10% - 65 y 25 – 50% >85 y Hörsel och kognition hos äldre Presbyacusis – interaktion med kognitiva störningar Lin et al, 2013; Lin & Albert, 2014 Positiv effekt av hörselrehabilitering vid presbyacusis och demens Amieva et al, 2016 Speech in Noise Test 90 Age, Years % Speech Perception, 20 80 20 70 30 60 40 50 50 60 40 70 80 30 20 0 10 20 30 40 50 60 70 80 High Frequency Pure Tone Average, dB HL Bar renäs, Wikstr öm 2000 Magnusson, 1996 Hörsel och kognition hos äldre Centrala auditiva störningar Central Auditory Processing Disorder (CAPD) CAPD har påvisats vid demens och vid impressiv afasi Gates et al, 1996, 2002, 2008; Idrizbegovic et al, 2011; 2013 Ramsing et al, 1996 Auditory function in early Alzheimer’s disease and Mild Cognitive Impairment Idrizbegovic et al, 2011 Pure tone audiometry Speech audiometry PB words in quiet (SPQ) In noise (SPN) 4 dB S/N Dichotic digits test (DDT) 136 subjects, mean age: 64 years (range 50-78) 1) AD; 2) MCI; 3) SMC Central Auditory Processing (CAP) dysfunction is highly evident in early AD, and even in MCI Evaluation of CAP might provide an auditory diagnostic complement in monitoring the progression of AD and MCI