Falun 110214
Dan Hellberg
Curriculum vitae
b.1953
Academic merits
PhD (Dr of Medical Sciences), Department of Women´s and Children´s Health, Uppsala
University 1987
Docent (associate professor), Department of Women´s and Children´s Health, Akademiska
Hospital, Uppsala University 1998
Professor, Department of Women´s and Children´s Health, Akademiska Hospital, Uppsala
University 2008
Clinical merits
Examined physician 1978
Registered physician 1981
Specialist in Obstetrics and Gynecology 1988
Obstetrician and Gynecologist, Department of Obstetrics and Gynecology, Falun Hospital
1988-1992.
Scientific positions
Superviser, R&D, Department of Obstetrics and Gynecology, Falun Hospital 1992-2002
Superviser, researcher, Institute of Clinical Bacteriology, Uppsala University 1993-2000
Superviser, researcher, Center for Clinical Research, Falun 2002-
Major research areas
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Cervical neoplasms including HPV infections, other sexually transmitted infections and
sexual behavior.
Memberships
On invitation
Global Alliance for International Advancement (GAIA), New York
Society for the Scientific Study of Sexuality
European Union Seventh Framework Program, Brussels
International Advisory Board
Strömstad Academy, professor
Others
International Federation of Obstetrics and Gynecology
Nordic Federation of Obstetrics and Gynecology
Swedish Society of Physicians
Previous memberships
American Association for Advancement of Science
New York Academy of Science
International Federation of Colposcopy and Cervical Pathology
Latvian Medical Academy
Scientific work
Publications
108 original articles
22 reviews or summaries
9 text books or extensive reports – editor/co-author
2
27 domestic scientific articles and reports
82 congress abstracts
Superviser
Previous superviser of Doctors of Medical Sciences
Bo Sikström. Epidemiology of cervical human papillomavirus infections and of genital warts.
1995 (accepted by the Medical Faculty and seven articles published, but no dissertation due
to personal reasons).
Maria Arvidson. Casual Sexual Contacts in Females. Thesis. Uppsala University 1996
Salah Elshibly. Characterization of Women with Ecological Disturbances in the Lower
Urugenital Tract. Thesis, Uppsala University 1997.
Krasimira Tchuodomirova. Sexually transmitted diseases and associated conditions in women
considering themselves healthy. Thesis, Sofia University, Bulgaria 2000 (first superviser).
Lars Holmberg. Health, Risk-taking behavior and sexuality in Swedish adolescents. Thesis,
Uppsala University 2007.
Annika Lindström (dissertation in 2008). Biochemical prognostic markers, and risk factors for
invasive squamous cell and adenomatous carcinoma of the cervix uteri. Thesis, Umeå
University 2010 (first superviser).
Corrine Holmgren. Tension-free vaginal tape operation in female urinary incontinence. A
long-term follow-up. Thesis, Uppsala University 2010 (first superviser).
Master of science
Maria Blennborn. Decision-making in in vitro fertilization. The role of the couple and the
transfer of one or two embryos, Dala University College, Falun, 2006.
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Superviser of ongoing PhD research students
Dr Raghad Samir. Biochemical markers in smokers, oral contraceptive users and during
menstruation in different stages of neoplasia of the cervix uteri (first superviser).
Samir R, Asplund A, Tot T, Pekar G, Hellberg D. Tissue tumor marker expression in smokers, including serum
cotinine concentrations, in women with cervical intraepithelial neoplasia (CIN) or normal squamous cervical
epithelium. Am Obstet Gyn 2009 (in press).
Samir R, Tot T, Asplund A, Pekar G, Hellberg D. Correlations between expression of eleven tumor markers, and
serum progesterone and estradiol in women with cervical intraepithelial neoplasia (CIN) or normal squamous
epithelium. Manuscript 2009.
Samir R, Asplund A, Tot T, Pekar G, Hellberg D. Changes in tissue tumor marker expressions in hormonal
intrauterine device and oral contraceptive users, in women with cervical intraepithelial neoplasia (CIN) or
normal squamous cervical epithelium. Manuscript 2009.
Dr Gyula Pekar. Ductal and lobular breast cancer Histopathology and combinations of tumor
markers; prognosis and differences.
Tibor Tot, Gyula Pekar, Syster Hofmeyer, Maria Gere, Miklos Tarjan, Dan Hellberg, David Lindquist.Molecular
phenotypes of unifocal, multifocal and diffuse invasive breast carcinomas. Pathol Res Int 2011;2011:ID 480960.
Tibor Tot, Mária Gere, Gyula Pekár, Miklós Tarján, Syster Hofmeyer, Dan Hellberg, David Lindquist, Tony
Hsiu-His Chen, Amy Ming-Fang Yen, Sherry Yueh-Hsia Chiu, László Tabár. Breast cancer multifocality,
disease extent, and survival. Hum Pathol 2011 (acc).
Dr Syster Hoffmayer. Unifocal, multifocal and diffuse growth pattern in breast cancer:
Histopathology and combinations of tumor markers; prognosis and differences.
Kristina Edman, dental hygienist. The impact of socioeconomic factors on periodontal
disease, dental decay and self perceived oral health and attitudes to dental services and
changes during a 25 year period (first superviser).
Kritina Edman, Dan Hellberg. Oral health in an adult population 35 – 75 year of age in the county of Dalarna,
Sweden in 1983 and 2008. 2011 (manuscript)
Dr Ulf Hållmarker. Fysisk Aktivitet – Hälsonytta och Risker vid Motionsidrott; deltagare i
Vasaloppet 1955-2010.
Superviser of ongoing PhD projects, not yet registered
Dr Emma Billström. Cervical neoplasia: natural history, characteristics and causes of
progressive disease, and risk factors: A 40-year follow-up study (first superviser).
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Per-Olof Rödöö. Diagnosis and etiology of benign paroxysmal vertigo in childhood. The role
of previously unknown serological markers (first superviser).
At present:
Rödöö P, Hellberg D. Creatine kinase MB (CK-MB) in Benign Paroxysmal Vertigo of childhood – a diagnostic
marker for a common but often unrecognized or misunderstood condition. J Pediatrics 2005;146:548-51.
Rödöö P, Hellberg D. The Creatine kinase-MB and -BB-associated Paroxysmal Behavior Alterations in
Childhood. Manuscript 2007.
Rödöö P, Hellberg D. Masturbation of girls in infancy and early childhood – Unexpected increase of creatine
kinase MB (CK-MB) and creatine kinase BB (CK-BB). Manuscript 2007.
Other projects
Superviser: EpiWux, epidemiological odontological project, Dalarna, 2007-.
The Odontological Research Committee, Dalarna, Sweden.
Adviser
National Institute of Health (NIH), USA (human papillomavirus infections) (previous).
International Bibliographical Centre Advisory Board, Cambridge, England.
Scientific collaborations
At Falun Hospital: Present: The IVF unit (2- or 3 gas system in blastocyst culture and
Embedding blastocysts in agarose and paraffin blocks) (2007).
Department of Obstetrics and Gynecology, Pediatrics, Clinical Chemistry and Clinical
Cytology and Pathology. Previous: Department of Internal Medicine and Urology,
Other previous or present: American Health Foundation, New York. Institutes of: Obstetrics
and Gynecology, Genetics and Pathology, Human Proteom Resources Department, Pediatrics,
Clinical Bacteriology and Clinical Chemistry, Uppsala University. Institutes of: Dermatology
and Venerology, Karolinska Hospital, Stockholm. Institute of Molecular Biology, Karolinska
Institute, Stockholm. Institutes of Obstetrics and Gynecology, Gynecological Oncology,
Virology, and Pathology, Umeå University, Sweden. Institutes of Pathology, Kuopio and
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Turku University, Finland. Latvian Medical Academy, Riga University, Latvia. Institute of
Venerology, Plovdiv University, Bulgaria. Institute of Obstetrics and Gynecology, Donetsk
University, Ukraine.
Other ongoing external collaborations
Docent Keng-Ling Wallin, Center for Molecular Medicine, Karolinska Institute, Stockholm,
Sweden (cervical cancer) (2007-).
Dr Anna Asplund, PhD, Institute for Genetics and Pathology, Akademiska Hospital, Uppsala
University, Uppsala, Sweden. The proteom project (preinvasive cervical lesions) (2006-).
Helena Biosciences, Sunderland, UK, Dr David Snell (agar electrophoresis) (2005-).
ABS laboratories, London, UK Dr Mira V. Doig (tobacco constituents) (2007-).
Professor Kari Syrjänen, Department of pathology and professor Stina Syrjänen, Department
of Odontology, , and co-workers, Turku University, Turku, Finland (cervical cancer) (2005-).
Professor Roger Henriksson and co-workers, Department of Oncology, Institute of Radiation
Sciences, Norrlands University Hospital, Umeå, Sweden (cervical cancer) (2004-).
Professor em. Ulf Stendahl, Stockholm, Sweden (cervical cancer) (2000-).
Professor Jan Gustavsson, Department of Women´s and Children´s Health, and Docent Peter
Ridefelt, Department of Clinical Chemistry, Akademiska University Hospital, Uppsala.
Docent Frank Niklasson and Dr Mattias Aldrimer, Department of Clinical Chemistry, and Dr
Peo Rödöö, senior physician, Department of Pediatrics, Falun Hospital, Falun. Dr Leif
Jansson, chief medical officer, Department of Clinical Chemistry and Dr Lars Skogsberg,
senior physician, Department of Pediatrics, Gävle Hospital, Gävle. Dr Per Bjellerup, head,
Department of Clinical Chemistry, and Dr Carl-Göran Arvidsson, senior physician,
Department of Pediatrics, Västerås Hospital, Västerås, Sweden (reference intervals in children
and adolescents where those are missing or unreliable). Dan Hellberg, Initiator and project
leader (2007-).
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Examination committee
Dr Nils Rodhe. Bacteriura without symptoms in men and women more than 80 years of age.
Intermediate control before dissertation, November 2006.
Dr Caroline Elmer, Karolinska Institute, Stockholm, May 2010
Referee
British Medical Journal
British Journal of Obstetrics and Gynecology
Tumor Biology
International Journal of Cancer
Journal of Cellular and Molecular Medicine
Recent Patents on Anti-Cancer Drug Discovery
Acta Oncologica
Human Reproduction
Sexually Transmitted Infections.
International Urogynecology Journal
Journal of Experimental and Clinical Assisted Reproduction
Journal of Reproductive Immunology
Journal of Reproductive Science
European Journal of Obstetrics and Gynecology and Reproductive Biology
Acta Paediatrica
Journal of Obstetrics and Gynecology Research
Journal of Chinese Clinical Medicine
European Journal of Public Health
Radiotherapy and Oncology
Acta Obstetricia et Gynecologica Scandinavica
Archives of Gynecology and Obstetrics
Pedagogics [Swedish/English]
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The University Course of Pedagogics, Uppsala University, 1988.
Docent lecture: Hormone replacement therapy of climacteric complaints, Department of
Women´s and Children´s Health, Uppsala University. Approved by the representatives of the
Uppsala University Pedagogics Faculty, 1988.
Author/Co-author
Hellberg D. On some possible etiological factors of cervix and penis cancer. Thesis, Uppsala
University 1987.
Hellberg D. Human papillomavirus infections: The female patient – clinical diagnosis and
treatment. In: Genital Papilloma virus infections and their sequele. Ed. Maibach HJ, Guildford
1988.
Hellberg D, Rylander E. Cervical intraepithelial neoplasi som sexuellt överförd sjukdom. Ed
Sandström E, svensk Lärobok i Venerologi, Studentlitteratur 1994; pp 273-8.
Hellberg D. HPV och carcinogenes – Cofaktorer. Att förebygga cervixcancer samt vaginal
och vulvacancer. ARG rapport no. 34, Västra Aros Tryckeri AB, Västerås, 1997.
Cachrimanidou A-C, Hellberg D, Nilsson S. Nioveckorspillret. Organon 1994.
Hellberg D, Nilsson S, Mårdh P-A. Epidemiology of bacterial vaginosis and some interrelated
conditions. In Bacterial Vaginosis, Oxford Clinical Publication, Oxford 1994; pp 3-15.
Mårdh P-A, Hellberg D. Genitala icke STD-relaterade infektioner. I Klinisk Bakteriologi.
Eds. Forsgren A, Kronvall G, Studentlitteratur, Lund 1995, pp 251-62.
Hellberg D. Smoking and cervical cancer. In Research Focus on Smoking and Women´s
Health, p. 19-59. Eds. Katherine P. Tolson and Emily B. Veksler. Nova Science Publishers
Inc, New York 2008.
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Hellberg D, editor. Histological and serological tumor markers and their clinical usefulness in
cancer: Cancer of the breast, lung, pancreas, liver, esophagus, colon, rectum, anus, skin, urinary
bladder, prostate, ovary, uterus and uterine cervix. Nova Science Publishers Inc, New York 2009.
1. Preface – Dan Hellberg, professor, Center of Clinical Research, Falun/ Dept of Women´s and Children´s
Health, Uppsala University, Uppsala, Sweden.
2. Introduction – Professor Michael J Duffy, Dept of Pathology and Laboratory Medicine, St. Vincent's
University Hospital, Dublin, Ireland.
3. Skin – Jochen Utikal, MD, MGH Cancer Center, Harvard Medical School, Boston, US.
4. Uterus - Uterus: Associate professor Alessandro D. Santin MD, , Dept Obstetric and Gynecology, Div.
Gynecologic Oncology, YALE University New Haven Hospital, US
5. Uterus (P2X) – George I Gorodeski, MD, PhD, professor, Dept Reproductive Biology, Case Western Reserve
University, Cleveland, Ohio, US.
6. Lung – Alissa K Greenberg, MD, Dept Medicine, New York University School of Medicine, New York, US
7. Esophagus – Daniel Vallbohmer, MD, Norris Comprehensive Cancer Center, University of Southern
California, Los Angeles, US and Cologne University, Cologne, Germany.
8. Gastric – Wataru Yasui, professor and chairman, Dept Molecular Pathology, University Medical School of
Biomedical Sciences, Hiroshima, Japan.
9. Penis – Dr Fernando A Soares. Department of Anatomical Pathology, Medical and Research Center, Hospital
do Cancer A C Camargo, Sao Paulo, Brazil.
10. Liver – John M Luk, MD, PhD, Dept Surgery, University of Hong Kong, China.
11. Colon – Dr Wendy L Allen. Department of Oncology, Centre for Cancer Research and Cell Biology, Queen's
University Belfast City Hospital, Belfast, Northern Ireland, United Kingdom.
12. Rectum – John M Reynolds, MD, Dept Surgery, Dublin University, Dublin, Ireland.
13. Anus – Malcolm J Moore, MD, Head - Division of Medical Oncology and Hematology,
Princess Margaret Hospital, University Health Network & Mt Sinai Hospital.
Chief of Medical Services - Princess Margaret Hospital. Toronto, Canada.
14. Prostate – Dr Thorsten Schlomm, MD, ass. Medical Director, Head Molecular Research, Martini-Klinik,
Prostate Cancer Center, University Medical Center, Professor Jörg F Debatin, MD, Head; Dr Alexander Kirstein,
MD; Ricarda Klein; Professor Uwe Koch-Gromus, MD, Hamburg, Germany.
15. Brain - Professor Roger Henriksson, head, Dept. Oncology, Umeå University Hospital, Umeå, Sweden.
16. Pancreas – Giuseppe Tonini, MD, PhD, Professor and Director of Medical Oncology, University Campus
Bio-Medico, Rome.
17. Breast – Tibor Tibor, associate professor, Dept Pathology and Clinical Cytology, Falun Hospital, Falun and
Dan Hellberg, professor, Center of Clinical Research, Falun/ Dept of Women´s and Children´s Health, Uppsala
University, Uppsala, Sweden..
18. Ovary – Maria Rosaria Raspollini, MD, PhD, Dept Human Pathology and Oncology, University of Florence,
Florence, Italy.
19. Cervix – Dan Hellberg, professor, Center of Clinical Research, Falun/ Dept of Women´s and Children´s
Health, Uppsala University, Uppsala, Sweden.
20. Summary – Dan Hellberg, professor, Center of Clinical Research, Falun/ Dept of Women´s and Children´s
Health, Uppsala University, Uppsala, Sweden and Professor Michael J Duffy, Dept of Pathology and Laboratory
Medicine, St. Vincent's University Hospital, Dublin, Ireland.
Key note lectures (on invitation)
Hellberg D. Human papillomavirus infections: The female patient – clinical diagnosis and
treatment. Xth World Congress of Obstetrics and Gynecology, Berlin sept 16-20 1985
Hellberg D. Genital human papillomavirus infections: State of the art. IIIrd International
Symposium on Vaginosis/Vaginitis, Madeira, Jan 25-29 1994.
Hellberg D. Riga Youth Health Clinic, Latvian Medical Academy, anniversary 1998, Riga.
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Hellberg D. The biological role of smoking, oral contraceptive use and endogenous sexual
steroid hormones in invasive squamous epithelial cervical cancer. Seventh International
Conference on Anticancer Research, Corfu, October 2004.
Hellberg D. Tumörmarkörer vid cervixcancer. Dalaseminarium Analytisk Kemi, Högskolan
Dalarna 2007.
Hellberg D. Single or combinations of tumor markers in cervical cancer – correlation to
prognosis, serum progesterone and estradiol, smoking and oral contraceptive use. Eight
International Conference on Anticancer Research, Kos, Greece 2008.
Hellberg D. Tumor Markers, HPV and Co-factors in Cervical Intraepithelial Neoplasia.
Annual Meeting of Slovakian Obstetricians and Gynecologists, Martin, sept 2010.
Hellberg D. Tumor Markers and Co-factors in Cervical Cancer. Annual Meeting of Slovakian
Obstetricians and Gynecologists, Martin, sept 2010.
Lectures
1970s
Urolithiasis
Kirurgiklinikerna vid Sandvikens sjukhus och Bollnäs sjukhus
1980s
Cervixcancer
Premenstruell spänning
Läkarkollegiet, Falu lasarett
Cervixdysplasier under graviditet
Klimakteriebehandling
Premenstruell spänning mm.
Kvinnokliniken, Falu lasarett
Cervix – funktion och Patologi
Barnmorskeutbildningen, Högskolan Dalarna (ett flertal år)
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1990s
Epidemiologins grunder
Cervikala Human Papillomvirusinfektioner
Kombinerad forskarutbildningskurs och ST-kurs i genitala infektioner, institutionen för
klinisk bakteriologi, Akademiska sjukhuset, Uppsala (årligen under andra halvan av 1990talet).
Cervix – patologi, infektioner, dysplasier och cancer
Internationell kurs i sexuellt överförda infektioner för gynekologer, Baltic International
School of Health, Karlskrona 1995.
Epidemiologins grunder
Cervikala Human Papillomvirusinfektioner
Genital herpes simplex
Vulvovaginal candidiasis
Internationell kurs i sexuellt överförda infektioner för gynekologer, Riga, Lettland 1995
(biträdande kursledare)
2000s
Att skriva en medicinsk artikel
Cervix
Cervixcancer – Rökning, p-piller, progesteron och östradiol
Borlängestudien – Tonåringar
Skillnader mellan muslimer, finländare och etniska svenska tonåringar
Tonåringars sexualitet
Invasiv cervixcancer – Tumörmarkörer och prognos
Tonåringars upplevelse av sin sömn
Teoretiskt eller yrkesförberedande gymnasium – Liv och leverne
Benign paroxysmal vertigo hos små barn
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Ett eller flera föredrag för:
Patologavdelningen, Falu lasarett
Kvinnokliniken, Falu lasarett
Ungdomsmottagningen, Falun
Barnmorskeutbildningen, Högskolan Dalarna
Barn och ungdomspsykiatriska kliniken, Falu lasarett
Barn och ungdomspsykiatriska mottagningen, Borlänge
Avdelningen för Klinisk Kemi, Falu lasarett
Barnkliniken, Falu lasarett
Popular Science
Livets port: Vinnare i Vetenskapens Världs tävling i populärvetenskap, Riksradion, P1, 1983.
Medicinska populärvetenskapliga artiklar varje lördag i Helsingborgs Dagblad och
Bergslagsposten, 1992-1993
Exempel på titlar: *Virusprov kan påvisa cancer *Doktorns fel patienten sjuk? *Rätt kost ger bättre syn *Var
tolfte kvinna drabbas av bröstcancer *Läkemedel har även positiva biverkningar *Påverkar tänderna hjärtat?
*Ledsmärtor vanligt vid infektioner *Nässpray det senaste för rökare *Fruktad graviditetskomplikation
*Förebyggande av bröstcancer *Den svenska pedofilen har fått ett ansikte *Genterapin kommer att göra succé
*Hjärtinfarkt och östrogen *Morgonhosta är det första tecknet *Titthålstekniken en revolution *Rätt kost bäst
hjälp vid tarmsjukdomar *Bastu och öl är ofarligt för friska *Forskning om Alzheimer gör framsteg *Astmans
gåta fortfarande olöst *Intensivbehandling av diabetes ger resultat *Hjärtinfarkt även med ”snälla” cigaretter.
Faktaunderlag och ‘spökskrivare’, ”Kvinnans sexualitet”, 12 artiklar, Aftonbladet, april och
maj 1995.
Initiator and founder
Riga Youth Health Clinic, Riga, Latvia, 1996
Other
Biographies in:
Who´s Who in the World (Marquis, USA); annually from 1995.
Who´s Who in Medicine and Healthcare (Marquis, USA) annually from 1997
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Who´s Who in Science and Engineering (Marquis, USA) annually from1997.
Who´s Who in America (Marquis, USA), 2008International Who´s Who of Professionals (Ericson publ., USA), 2010
International Biographies (Cambridge, UK) 1996.
Men of Achievements (Cambridge, UK) 1996.
Dictionary of International Biography (Cambridge, UK) 1998.
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