CUTTING EDGE BIOMOLECULAR SCIENCE 2014 SFBBM SYMPOSIUM • MARSTRAND Wednesday Thursday 24 September Friday 25 September 26 September 08:30-09:15 How dysfunctional replisomes signal cell cycle arrest Peter Burgers, Washington University 09:00-09:45 Protein kinase CK2 - at the crossroads of signaling networks and implications for pathological rewiring of regulatory pathways David Litchfield, University of Western Ontario 09:15-09:45 Human mitochondrial DNA maintenance in health and disease Sjoerd Wanrooij, Umeå University 09:45-10:15 New fluorescence techniques reveal NK cell receptor dynamics at the molecular level Sofia Johansson, Karolinska Institutet 09:45-10:30 Round table discussion 10:15-10:30 Structure-based ligand design to overcome CYP inhibition in drug discovery projects Gisela Brändén, University of Gothenburg Careers in research - why, how, when and where? Virginia Zakian, Princeton University Emma Sparr, Lund University Henrik Zetterberg, University of Gothenburg Marianne Quiding-Järbrink, University of Gothenburg Chair: Elias Arnér 10:30-10:45 Importance of rigorous enzymology in drug discovery the case of PARP inhibitors Herwig Schüler, Karolinska Institutet 10:45-11:00 Drug discovery at the single molecule level Anders Gunnarsson, AstraZeneca R&D 10:30-11:15 Coffee and exhibition Room ”Vinden” 11:00-11:30 Coffee and exhibition Room ”Vinden” 11:15-11:30 Catalytic rates of yeast DNA polymerase ε Rais Ganai, Umeå University 11:30-12:00 Biochemical properties of the essential S. pombe Pfh1 helicase Nasim Sabouri, Umeå University 11:30-11:45 Biochemical profiling of DNA binding in wild-type and mutant p53 with CETSA Rebecca Dovega, Karolinska Institutet 12:00-12:15 UL52 primase interactions in the HSV-1 helicase-primase complex are affected by antiviral compounds and mutations causing drug resistance Isabella Muylaert, University of Gothenburg 11:45-12:00 Transcriptional mutagenesis - p53 protein as probe of biological effects Kristian Dreij, Karolinska Institutet 12:15-12:30 A presentation of the MBB/SciLifeLab protein science facility Tomas Nyman, Karolinska Institutet/SciLifeLab/PSF 12:00-13:30 Lunch 12:30-13:30 Lunch 12:55-13:00 Welcome to Cutting Edge Biomolecular Science Elias Arnér, President SFBBM 13:30-14:00 Getting to the core of CorA - defining the molecular building blocks of a magnesium channel Mikaela Rapp, Stockholm University 13:30-13:45 Structural architecture and selectivity characteristics of protoncoupled peptide/drug transporters Fatma Guettou, Karolinska Institutet 13:00-13:45 Pif1 family helicases promote replication fork progression Virginia Zakian, Princeton University 14:00-14:30 Proteins regulating membrane shape and cell surface dynamics Richard Lundmark, Umeå University 13:45-14:00 Live cell imaging of mitochondrial dynamics and function in dendrites and spines Kaliaselvan Krishnan, KTH 13:45-14:15 Biomarkers for Alzheimer’s disease - our most common brain amyloidosis Henrik Zetterberg, University of Gothenburg 14:30-14:45 Biophysical characterization of membrane-interacting glycosyltransferases Scarlett Szpryngiel, Stockholm University 14:00-14:45 The Svedberg prize ceremony and lecture Lecture hall Suggested transportation by public transport: (Tickets are sold by Västtrafik and/or SJ.) 11:40-11:58 Train 3746 towards Uddevalla departs from Göteborg C. Arrives at Ytterby station 11:58. 12:08-12:36 Bus ”Marstrand Express” leaves Ytterby station. Arrives at Marstrand färjeläge (terminal) 12:36. 14:15-14:45 14:45-15:00 Compartmentalized single cell analysis - antibiotic susceptibility and Mechanisms of cellular uptake of the antisecretory peptide AF-16 protein screening Maria Matson-Dzebo, Chalmers Helene Andersson-Svahn, KTH 14:45-15:30 Coffee and exhibition Check-in 15:00-15:30 Coffee and exhibition Room ”Vinden” 15:30-15:45 Single molecule investigations of transcription factor kinetics living bacterial cells Johan Elf, Uppsala University 15:30-16:00 Lipid-protein co-aggregation in amyloid systems Emma Sparr, Lund University 15:45-16:00 Simultaneous determination of Nrf2, HIF and NFκB activation at single-cell resolution Katarina Johansson, Karolinska Institutet 16:00-16:30 Successes and failures in structure-based discovery of GPCR ligands Jens Carlsson, Stockholm University 16:00-16:15 Desensitization of GPCRs - physiological and pharmacological concentrations of angiotensin II yield distinct differences in AT1 receptor signaling Kristoffer Bernhem, KTH 16:30-16:45 Studying bicelle morphology with NMR diffusion spectroscopy and two-way data decomposition Johannes Björnerås, Stockholm University 16:15-16:30 Some like it hot - biomolecule analytics using MicroScale Thermophoresis Nicholas Luzzietti, NanoTemper Technologies 16:45-17:00 Heme A synthase in bacteria depends on two extracytoplasmic cysteine residues Lars Hederstedt, Lund University 16:35-17:00 Annual Proceedings of SFBBM Årsmöte för Svenska föreningen för biokemi, biofysik och molekylärbiologi 17:00-17:15 Phosphoryl and sulfuryl transfer reactions - challenges in interpreting experimental and theoretical data Lynn Kamerlin, Uppsala University 17:00-19:00 Social activity Meet up in hotel lobby 17:15-17:30 Sizing of spots at least seven times smaller than the resolution of the LSM used by Scanning Inverse FCS Stefan Wennmalm, KTH 19:00-20:00 Dinner 17:30-19:30 Poster session, mingle and exhibition 20:00-22:00 Poster session, mingle and exhibition Room ”Vinden” Room ”Vinden” 19:30 Conference dinner 14:45-15:30 Coffee and exhibition Room ”Vinden” 14:54-15:45 Bus ”Marstrand Express” departs. Arrives at Göteborg C / Nils Ericson Terminal Tickets are sold by Västtrafik or SJ. SFBBM Svenska föreningen för biokemi, biofysik och molekylärbiologi Swedish society for biochemistry, biophysics and molecular biology