HIV och tbc co‐infektion i Stockholm 1987‐2010 Maria Norrby
• 127 co‐infekterade
Female;
55; 43%
Male;
72; 57%
• HIV‐kohorten: 8401, 31% kvinnor
• Tbc‐kohorten: 3323, 48% kvinnor
Antal tbc‐diagnoser per år
14
12
No. of patients
10
8
men
6
women
4
2
0
1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
Year of TB diagnosis
Ursprung
Geographic distribution
50
45
40
Number of cases
35
30
female
25
male
20
15
10
5
0
African
Asian
European (excl.
Sweden)
Swedish
Latin American
CD4 vid tbc‐diagnos
CD4 at time of TB diagnosis
30
25
Frequency
20
15
Frequency
10
5
0
50
100
150
200
250
300
350
400
450
CD4 (cells/mm3)
500
550
600
650
700 More
Lokalisation av tbc
TB‐location
Sputum smearpos
44%
Extrapulmonary
25%
Pulmonary
engagement
75%
Sputum smearneg
35%
Sputum smear
N/A
21%
HIV‐behandling vid tbc diagnos
NVP‐baserad; 2; 2%
EFV‐baserad; 4; 3%
PI‐baserad; 15; 12%
3 NRTI; 4; 3%
1‐2 NRTI; 12; 9%
Ingen
behandling; 90; 71%
Behandlingstid för tbc
70
Duration of TB treatment in months
60
Number of cases
50
40
Second‐line
MDR
First‐line
30
20
10
0
5 m
6 m
7‐12 m
> 12 m
N/A
Biverkningar under tbc‐behandlingen
Side‐effects
25
20
20
15
12
10
11
10
Count
8
7
5
5
4
4
2
0
1
1
Resultat av tbc behandling
Not evaluated
(moved)
5; 4%
Relapse
7; 5%
Successfully treated
107; 84%
Unsatisfactory; 15;
12%
Treatment interrupted
1; 1%
Death
7; 6%
CD4 ‐ Outcome
Tid från HIV‐diagnos till tbc‐diagnos (dagar)
Duration from HIV diagnosis to TB diagnosis in days
7000
6000
Days from HIV diagnosis to TB diagnosis
5000
4000
hivDiagnosAr
3000
2000
1000
0
1980
‐1000
1985
1990
1995
2000
Year of HIV diagnosis
2005
2010
2015
I samarbete med
• Carolina Wannheden, LIME, KI
• Katarina Westling, Infektionskliniken, Karolinska
• Ingela Berggren, Smittskydd Stockholm
