2012-06-21
Biobanks, an under‐used resource
Mark Divers
Karolinska Institutet Biobank och BBMRI.se
Vinnova‐VR workshop , Stockholm, juni 2012
Forskningsinfrastruktur för industriella innovationer
But biobanking is hot!
• Big interest
• >$1B technology spend per year
• Big population studies appeared
• Hunt, deCode, UK Biobank, LifeGene, LifeLines, Kadoorie
• Big analysis transformation
• Genetic and protein technologies
• Big discussion
• Many hopes, many fears
Growing impact on medical research
Huge public health opportunity 2
1
2012-06-21
What is a biobank?
• Organiserad collection of biological samples
– Often human
• Archived long‐term
– Frozen: ‐20, ‐80, ‐190°C
• Searchable & accessible
– Samples and data
• Used for research, development and healthcare
– Described as gold‐mine!
• Regulated by law
MD1
Biobank landscape of Sweden
• 579 Biobanks
2
2012-06-21
Biobank landscape of Sweden
– for healthcare
Tissue114Msampels
Cells28,7M
Blood/plasma4530000
Serum2200000
DNA/RNA69000
Bone110000
Others106000
Biobank landscape of Sweden
– for research
Blood/Plasma4,2M
Serum2,3M
DNA/RNA572000
Tissue51000
Urin230000
Salivia112000
Other47000
3
2012-06-21
The biobanks of KI and BBMRI.se are a rich source of samples: 150 studies
Population cohorts
• TwinGene, LifeGene, EpiHealth
• Karma, Stockhom‐2
Disease based studies
• Cancer
• CV
• Neurological
• Inflammatory
• Immunological
Quality registers
A good climate for biobank-based
research in Sweden
• Well‐characterised population
•
personal number system
•
systematic registries
• Track‐record
•
Eg Swedish Twin Registry ”TwinGene”
• Large population cohorts emerged 2009
•
LifeGene, EpiHealth
• Long‐term research impact
• Public support
4
2012-06-21
But challenges too
• Fragmentation
• Organisational
• Logistic
• Economic
• Complex ethico‐legal landscape
EU BBMRI initiative: our chance to
create biobanks of the future
• Technology: test and apply the best!
• Network: connect modern biobanks!
• Vision: 300 biobanks throughout EU
• Harmonise: evolve common standards!
• Add big public health value!
Swedish Science Research Council and KI fund BBMRI.se
for 5 years
5
2012-06-21
large-Scale Swedish Biobanking (SSB);
a service for big national studies
Some biobank accounts May 2012
Total
# studies
150
# samples
2 634 210
# donors
233 950
# DNA samples 197 519
# withdrawals >225 000
KIBB
140
584 578
153 201
138 963
>175 000
BBMRI.se
10
2 049 632
80 749
58 556
>50 000
6
2012-06-21
Creating a BBMRI.se national network
Progressive build up in medical universities
• Goteborg node
• launch Jan 2012
• 1st project: Scapis
• Malmö node
Co‐ordinated:
• Sample format
• Data format
• Processes
• Equipment & consumables
• Access and use
• launch 1Q2012
• 1st projects: EpiHealth, MKC, MFM • Linköping, Umeå, Uppsala to come
• Linköping launch 1H2013?
• Projects identified
Starting co‐ordination with healthcare biobanking
13
Unifying Swedish biobanks further
University + Healthcare biobanks
• National common infrastructure
– VR ‐ SKL declaration
• Regional partnerships, eg
– Uppsala biobank
– Göteborg
– Region Skåne
– KI – SLL
7
2012-06-21
Why are we biobanking?...
Study
publications
GALLSTEN
… to advance medical research!
• Combine with modern bio‐analysis
• Systematic
• Statistical power
4
PAIN
2
BAMSE
8
SCALE
15
Ekonomiskt beteende
2
TwinGene & Euroclot
13
HARMONY & SATSA
12
KTS
1
CAPS
40
Totalt
• Huge potential for public health
97
Emerging highlights
• Multiple Sclerosis
• TwinGene
• Broad
• Influenza Like Illnesses
• Prostate Cancer
What is the value of biobanking?...
Multiple Sclerosis research gives a great example*
• ~17K MS cases in Sweden
• Many represented in our biobank
• New therapy, Tysabri™
• Monoclonal antibody
• Very effective, very expensive
• Serious side effects in some (polyoma viral cross‐reacton)
• Screen MS biobank for polyoma virus
• Save big drug cost (200KKr/patient/yr)
• Save some lives, improve others
• Match a good drug to the right patients *T Olsson et al
http://www.pharmatimes.com/Article/12‐01‐23/New_Tysabri_label_to_personalise_treatment.aspx
16
8
2012-06-21
Biobanking adds big value
Clinical practice
Better screening, diagnosis and treatment match
Health economy
Better public health for lower cost
eg HPV, MS
Drug development
Matching patients to treatments
eg MS, HIV, HPV
Ethical credibility
Increased trust and support
eg HPV
2012-01-03
Mark Divers
Biobanks for industrial innovation?
Discovery & Development
• Pharmaceuticals
– Biomarkers
– Patient subtyping
– Metabolites
– Safety profiling
• Diagnostics
• …
9
2012-06-21
Acknowledgements
The BBMRI Crew
Joakim Dillner
Jan-Eric Litton
Mats Hansson
Göran Hallmans
Ulf Landegren
Joakim Galli
Lars-Olof Hansson
Joyce Carlsson
Lisen Arnheim-Dahlström
Sofie Pettersson
Martin Fransson
Loreana Norlin
Maria Anderberg
The LifeGene Crew
including
Jens Mattsson
Kicki Kjaergaard
Mats Thurman
Camilla Björk
Thomas Bergman
More info
http://ki.se/kibiobank
www.bbmri.se
www.lifegene.se
The Biobank Crew
Lab Operations
Carita Rask
Jaspal Singh
Cecilia Agardh
Peter Arnerlöv
Anci Carman
Pia Hillelson
Camilla Lagerberg
Vian Osman
Amina Said
Anette Selander
Johanna Smith
Siwonne Andersson
Emma Ridell
William Day
Valentina Novak
Karin Lindqvist
Biobank IT
Eva Büren
Staffan Bergh
Jonas Birgersson
Ulrika Bohlin
Jesper Lind
Johan Stenninger
José Tapia
Anni Åsberg
Niclas Ahlin
Biobank Development
Gunnel Tybring
Customer Relations
Tove Rylander-Rudqvist
Cecilia Björkdahl
Quality
Anette Petersson
Mirja Larsson
Project coordination
Anders Brinne
Others @ KI
Henrik Grönberg
Per Hall
Nancy Pedersen
Rune Franson
Per Spångeus
19
10
